Enclomiphene is a more selective isomer of clomiphene, acting antagonistically in the hypothalamus to increase testosterone, while its counterpart, zuclomiphene, has anti-androgenic activity and a longer half-life.

“So clomophene has two is it stereoisomers, I believe. Yeah. One one is basically a mirror image of it. Yeah. So it's like zucchene and enlomophene. And nclomophene is seemingly the more selective and actually antagonistic in the hypothalamus. So it's kind of like doing the thing you want from the Clomid whereas the zucchophene is like anti- gonadit like it's providing uh almost like a anti-androgenic type activity in a way that is not as selective as like a pure serum. So when you think serum you're thinking something that antagonizes estrogen receptors purely in the hypothalamus but then leaves estrogen activity everywhere else. Bone integrity is maintained cardiovascular etc. molecule everything is kind of backfilled accordingly except for right there in your brain where you want your brain tricked into thinking make more testosterone. So colomophene it also has a shorter halflife significantly less I think it's 10 hours off the top of my head and zucophene is like days or something. So the actual ability to maneuver the drug like phiccoinetically too if you have a bad side effect or something can't even get off it as easily with clomid because you have this big chunk of it as zucchine.”