Paul Saladino· MD
cortisol has pro-aging effects in fact I think a human and animal study show that you can reproduce all of the phenotype of all the signs of aging external by administering a very high dose of cortisol for a long period of time
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
cortisol has pro-aging effects in fact I think a human and animal study show that you can reproduce all of the phenotype of all the signs of aging external by administering a very high dose of cortisol for a long period of time
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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I think that there's a lot of validity to thinking about cortisol as an aging hormone there are actually papers published review papers asking the question is cortisol an aging hormone and I think that literature there and the evidence is pretty robust that it is and you don't want your cortisol to be chronically tonically high in general