Andrew Huberman· PhD
2% is a good rule of thumb.
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2% is a good rule of thumb.
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whether you're looking at a 903 or a 776 the free testosterone is probably what's more important and with my testosterone of 7 to 76 now my free testosterone is much higher than it was when my total testosterone was 903 why is that because my sex hormone binding globulin is much lower now
the free testosterone which is the biologically active represents only about one to three percent of total testosterone
Most of testosterone is bound 2% is free and so 50% alumin 44% shbg 4% corticotropin binding globulin oh I didn't know that I thought shbg was The Lion Share but it's split relatively equally with albumin as well Al 50% Albin 44 and then 4% Corin Bing G small percentage 2% free
uh most of testosterone is bound 2% is free
given that free testosterone is typically estimated I guess we can talk a little bit about testosterone measurements you were mentioning earlier that there's a direct way to measure free testosterone I was unaware of that um do you look at free Androgen index where you're just taking the ratio of testosterone to shbg so you're taking the ratio of two things that are directly measured is that a better proxy for what's happening physiologically than this indirect uh calculation of free testosterone which I mean again if my memory serves me correctly free testosterone is a calculation based on testosterone shbg and albumin is there anything else that factors into it
you're measuring total testosterone you're measuring sex hormone binding globulin you're measuring albumin you use those to estimate the free amount of testosterone but that's still an estimate
So, the SHPG levels will be dictated by age, will be dictated by liver health to some extent, will be dictated by other medications, especially oral formulations. Um, insulenic signaling as well hugely implicated. If you're on a ketogenic diet, you can absolutely expect your SHBG levels to be through the roof and your free test to be much lower. So carnivore diet guys, there's a reason they eat fruit now. It's because their free test levels are all [ __ ] and their total test levels were high and they thought it was fine. But in reality, they had like borderline hypoganatal free test levels often because they were overlooking the fact that insulenic signaling is needed to actually get SHBG to a meaningfully reasonable level for a male.