The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
GnRH, for those of you that don't know actually comes from neurons in the hypothalamus that then, literally reached down into the pituitary and trigger the release of all the things that control fertility, luteinizing hormone, follicle-stimulating hormone, et cetera.
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Then some biological clock, which is still not clearly understood-- it's probably not leptin coming from body fat. Again, unlike in the female, it's probably not leptin coming from body fat. But some other signal arrives to the hypothalamus, removes that inhibition, and GnRH, gonadotropin-releasing hormone, is now released onto the pituitary. A bunch of hormones are deployed from the pituitary as a consequence. The two most important ones for the context of this discussion are follicle-stimulating hormone and luteinizing hormone. Follicle-stimulating hormone and luteinizing hormone travel to the testes, and they're going to do two main things. One, they're going to trigger the production of testosterone. And they're going to trigger the production of the sperm themselves.
We've got GnRH from the hypothalamus. That's going to be a player. We have FSH, follicle-stimulating hormone, although the name's a little bit of a misnomer in the context of spermatogenesis, because in the context of spermatogenesis, there is no follicle. What we're really talking about is FSH for stimulating the maturation of the sperm cell, so not egg follicle but sperm cell. But we still have GnRH, FSH, LH, and rather than the ovary being the target of those hormones, it's going to be the testes.
so you know that pituitary produces two hormones LH lutenizing hormone and FSH follicle stimulating hormone which then stimulates the testicle so the lutenizing hormone hormone stimulates the leig cells to make testosterone and then the follicle stimulating hormone or FSH stimul sperm production
LH goes to ladic cells and produces testosterone FSH goes to the CI cells and produces sperm right the two functions of the testicle are basically sperm and testosterone
So the top of that is the G&RH stimulates pituitary output of LH luteinizing hormone which acts on latic cells in the testes and follical stimulating hormone that acts on certly cells as well. And this is the and this we'll definitely get into that email you sent me about you know fertility and whatnot. Those will go down to the testes and stimulate the production of intraesticular testosterone as well as assist with the production of sperm and maintenance of fertility.
So the ginadotropins that come out of the pituitary, they elevate upstream and G&R as well in response or lack thereof to adequate and there's so many to lesser magnitudes but primarily androgen receptor activation and estrogen receptor activation.
You need proper amounts of testosterone and FSH. Think of it as flowering a plant. you need the water and you need the sunlight. So if testosterone and FSH are key to get normal amounts of tea, testosterone, you're going to need LH which drives it.