Initiating hormone replacement therapy after a decade or more of hypoestrogenism may lead to adverse events. — Whalespan
Initiating hormone replacement therapy after a decade or more of hypoestrogenism may lead to adverse events.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“the big issue there was that these people were hypoestrogenic for 10 plus years in one group and then started back on the hor hormones and in that circumstance they'd already been put into this higher risk category and their body had adjusted to not having the hormones and when reexposed they had more Adverse Events”
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