Nitric oxide stimulates NF-kappa B (NFkB), the master regulator of the inflammatory cascade, leading to the activation of prostaglandins and inflammatory mediators.

“also nitric oxide stimulates itself tryptophy hydroxylase it stimulates something called nfkb nuclear Factor Kappa B I think it's called which is like the master regulator of the of the diaphlammatory Cascade if you activate nfkb the activating proxin locks and if there's sufficient poof around which there always is the new triggering a lot of these inflammatory mediators as well”