Combining carbohydrates with polyunsaturated fatty acids causes insulin resistance and weight gain.

“PUFAs are the problem, not carbohydrates.”

“I think people people know what their fatty acid composition is based on what they're consuming but I think it's so important to highlight to people how damaging these oils are and how insidious they are in our foods and how we're often told that they're good for us based on really bad information and how they're just totally screwing up our metabolism and like you said our satiety and fat loss and probably really I I'm I'm with you I think these are some of the main culprits and insulin resistance”

“eating polyunsaturated vegetable oils is very damaging in the setting of excess carbohydrates because of insulin”

“it's a real dichotomy between the way that stearic acid works in humans and linoleic acid work in humans and even oleic acid this is some concern about monounsaturated fatty acids the big rabbit hole here involving the way that these fatty acids undergo beta oxidation in the mitochondria and the ratio of nadh to fadh2 and that ratio may be a key determining factor in whether mitochondria turn off or turn on when mitochondria turn off essentially what i'm saying here is that there are so many reactive oxygen species producing that mitochondria because of reverse electron transport those reactive oxygen species send a signal to the insulin receptor to become insulin resistant and generally speaking when a mitochondria has more reactive oxygen species it becomes insulin resistant again there's a lot of nuance here but the fats that we eat can determine whether our mitochondria become insulin resistant or insulin sensitive meaning whether they burn fat or whether they shut off completely to the actions of insulin”

“if your metabolism is broken if you have underlying insulin resistance then those insulin spikes are going to be disordered because your body's not going to respond to them because you have insulin resistance at the cellular level again i think the main driver there at the molecular level is polyunsaturated vegetable oils”

“fats can kill especially if they're of Napoleon saturated kind so we we just foreshadowed a lot of cool things we talked about we talked about serotonin we talked about estrogen you mentioned probably unsaturated fats or pufas from seed oils primarily”