The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
insulin resistance score which is the homa ir which is calculated with fasting insulin and fasting blood glucose declined actually more in the natural moderate fructose group minus 0.37 versus minus 0.29 in the intervention group with low fructose the comparison between groups was not did not reach significance the p-value was 0.12
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if you restrict processed fructose and you include 120 grams of carbohydrates from food a day they still didn't lose any of the benefits that's pretty significant and it falls in mind what we saw from uh joshua rubino to study
differences in diet compositions at baseline and among intervention groups there were 480 calories from fruits in the 1 500 kcal group 540 calories from fruit in the moderate fructose diet 1800 kcal group and the same 540 calories from fruit in the 2000 calorie diet now all of these diets are much lower than what i do i'll talk in a moment about how many calories i do but you can see that 540 calories from fruit fruit is fructose and glucose but all of those carbohydrates are four calories per gram you're looking at over 100 grams of fruit in these people and there was no decline in the benefits that being weight loss or improvements in metabolic syndrome parameters and in the moderate natural fructose group there was a decline in uric acid which is just as big as the no processed fructose group meaning that 100 grams of fruit per day did not raise uric acid one bit in these people
guess what eliminating processed fructose was the main mover when people added back in moderate amounts of fruit there was no decline in the benefits in fact what they say is weight loss was higher in the moderate natural fructose group than the low fructose group compared with baseline each intervention diet was associated with significant improvements in the secondary outcomes those being symptoms those being those being metabolic syndrome parameters insulin resistance etc
each intervention diet was associated with significant weight loss compared to baseline meaning that a low fructose diet overall or a moderate natural fructose diet what they did in the study was they took out all synthetic quote unquote sources of fructose high fructose corn syrup sources from people's diets everyone improved in one group they allowed them to include moderate amounts of fructose per day leading to between 400 and 600 calories per day from fruit and they look to see what happens guess what eliminating processed fructose was the main mover when people added back in moderate amounts of fruit there was no decline in the benefits in fact what they say is weight loss was higher in the moderate natural fructose group than the low fructose group compared with baseline each intervention diet was associated with significant improvements in the secondary outcomes those being symptoms those being those being metabolic syndrome parameters insulin resistance etc