Paul Saladino· MD
essentially that this is controlled by our adipose tissue so it's the fat that becomes insulin resistant first
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
essentially that this is controlled by our adipose tissue so it's the fat that becomes insulin resistant first
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so there's some kind of threshold at which the adipose tissue says no mass i can't take any more and it and it stops listening to the signal it becomes insulin resistant
But by that it's the fat tissue. And I don't want to get ahead of us, but my view is that among if you look at tissue level insulin resistance is it starting in the muscle or the liver or the fat. I'm very much an advocate of the fat first focus when it comes to insulin resistance from that slow progressive. It settles in over years and it may take, you know, weeks to months in order to reverse.