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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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What Causes Insulin Resistance? — Whalespan

Content›Video›What Causes Insulin Resistan…

What Causes Insulin Resistance?

Paul Saladino6m · 2020-07-27

Claims Made

14

Claims Supported

13

Support Rate

93%

Support rate

13 of 14 claims supported

13 supported1 partial / not

Claims from this content

11

✓Well SupportedSystemic insulin resistance is distinct from the normal physiological glucose sparing observed in muscle on low-carb diets.✓Well SupportedThe threshold for adipose tissue saturation leading to insulin resistance is lower in Asian populations compared to Caucasians.◐Partially SupportedInflammation, independent of diet, can cause insulin resistance by influencing the adipocyte threshold at which it becomes insulin resistant.✓Well SupportedAdipose tissue is the primary site for slow, progressive insulin resistance that develops over years and may take weeks to months to reverse.Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Low-carb and ketogenic diets do not cause pathological insulin resistance; they induce glucose sparing in muscles.

✓Well SupportedInsulin acts as an anti-catabolic agent in muscle and adipose tissue, and at lower doses, reduces circulating fatty acids.

◐Partially SupportedIndividuals with autoimmune conditions like Sjogren's or rheumatoid arthritis are often insulin resistant, likely due to an interaction between adipose tissue amount and systemic inflammation.

◐Partially SupportedInsulin regulates gluconeogenesis in the liver.

◐Partially SupportedInsulin's primary role is to suppress glucagon secretion in insulin-sensitive pancreases.

◐Partially SupportedShoving glucose into cells requires the highest circulating amount of insulin compared to insulin's other functions.

◐Partially SupportedIn a ketogenic state, the liver increases gluconeogenesis.