Andrew Huberman· PhD
IGF-1 that is released directly due to growth hormone signaling-- usually, the growth hormone comes from the pituitary and binds to the liver where usually, it has a half life of about a week, where the paracrine or autocrine-- think of it as like the peripherally acting or acting in the muscles itself, which is also helpful-- is released and is not as concerning because it's not related to insulin resistance, but it is related to the training itself.