Neurocircuitry drives the inability to control eating in bulimia and binge eating disorder, overriding leptin and insulin signals.

“They are simply driven from the inside without question by way of neurocircuitry. They are driven from the inside to ingest far more food than they need. And in some cases than they would want to eat. So, it's a lot like the habit that we described for anorexia, it's almost like it's turned into a reflux once they get going, all the homeostatic signals are being overridden, all the signals from the body, the leptin, the insulin, the glucose, all that stuff has cosmically sky high.”