Bryan Johnson· Author
If they're intolerable, I'll switch to no-DAC + Ipamorelin, daily.
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
If they're intolerable, I'll switch to no-DAC + Ipamorelin, daily.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
This is what most clinicians prescribe and most of the peptide community uses. The tradeoff: less clinical trial data, daily injections, more anecdotal evidence base.
What we're considering: Start with DAC at half dose 2.4 mg, then if well tolerated escalate 4.8 mg, weekly injection. If side effects aren't tolerable, switch to no-DAC + ipamorelin (100 mcg then 200-300 mcg daily, before bedtime).
Or, Run both head to head. 2 weeks DAC, 2 weeks no-DAC + ipamorelin and compare.