Andrew Huberman· PhD
Early results were extraordinarily positive. 50% of patients who use the ketogenic diet became seizure-free. And another 35% had a 50% or greater reduction in their seizure frequency, so about 85% efficacy rate.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Early results were extraordinarily positive. 50% of patients who use the ketogenic diet became seizure-free. And another 35% had a 50% or greater reduction in their seizure frequency, so about 85% efficacy rate.
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And so in the 1970s, the ketogenic diet was resurrected at Johns Hopkins for these treatment-resistant cases. And lo and behold, it works-- not for all of them, but it works in-- about 1/3 become seizure-free. And these are people who've tried everything and nothing's working. So 1/3 become seizure-free. Another third get a clinical benefit, meaning a 50% or greater reduction in their seizure frequency. And the other third, it doesn't seem to work.