Paul Saladino· MD
so the branch in amino acids together with tyrosine and phenylalanine uh compete with elcryptophan for the passage to the blood-brain barrier uh and basically when you're consuming light leucine you're going to decrease the amount of free tryptophan in the brain which means you're going to produce less serotonin guess what this does lowers your cortisol right so that's that's probably one of the most anabolic effects of leucine that almost nobody talks about uh but several studies show that it could Minister the BCAAs it doesn't have to be just like losing but let's say you take all over the three of them the scene as you will see in a valiant right yeah yeah they usually sell them as bodybuilding supplements in capsules so you take a take about two to three grams of those they didn't animals but they're about to also repeat it in humans uh in fact that that combination is just something called acute tryptophan depletion for mood studies for they they mix BCAA with either l-tyrosine or l-phenylalanine because either one of those is a precursor to dopamine right and when you feed those right but it don't feed any tryptophan they're gonna out-compete the crypto fan and basically you're gonna have more l-tyrosine or more annual in your brain and because the the enzymes that synthesize dopamine or serotonin they're actually they're you know at rest Baseline is actually they're unsaturated when they give them these nutrients they're going to synthesize more of what you get which is more dopamine in this case right but Doberman has an anti-catabolic effect basically has an anti-serotonin effect anything that is pro dopamine is anti-serotonin in other words anything that is anticortisol so by given to Lucia I'm thinking a lot of the anabolic effect may come from aside from the stimulating muscle protein synthesis directly there's a metabolism called hmb very very popular as a supplement these days yeah yeah um right but Lucine I think has an anabolic effect which is has to do with its Antico anti-serotonin hands anti-cortisol effect