A significant drop-off in embryo development after day three post-fertilization can occur due to male genome contribution issues.

“I am not a urologist but definitely when I have a male who you know needs a sperm extraction maybe he's had a prior vasectomy maybe he's got very low sperm counts and we're going and we're doing a sperm extraction procedure that potentially if you have a patient who has an abnormal DNA sperm fragmentation and even with ixie has this drop off an embryo growth after day three because the sperm are still being made the same way right are they still fragmented that potentially the ejaculatory process could cause some of that fragmentation in certain men”