Andrew Huberman· PhD
ketamine is an nmda receptor blocker antagonist and yet we know that a lot of the changes in the brain that underly the transition from a depressed state to a non-depressed state involve neuroplasticity
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
ketamine is an nmda receptor blocker antagonist and yet we know that a lot of the changes in the brain that underly the transition from a depressed state to a non-depressed state involve neuroplasticity
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if people do this twice a week dosing regimen so ketamine twice a week for three weeks total they find that when they end that 3 weeks they get some ongoing relief from their depressive symptoms which can extend months or more before they have to repeat the twice a week for 3 weeks regimen
when thinking about how chemicals like ketamine or any other substance for that matter can modify brain circuits in order to change them and provide relief from depression or some other psychiatric challenge that always always always there is a requirement for engaging in anti-depressive behaviors as a way to further reinforce whatever positive changes have come about through the drug treatment as a friend and colleague of mine who's expert in this area once so aptly said Better Living Through Chemistry still requires Better Living
but that when those treatments are stacked fairly closely together that there is some durability some ongoing relief from depression
that it does seem to provide depression relief where other approaches have not but that the depression relief tends to be pretty short-lived unless it's applied in this multi- times per week over multiple weeks kind of fashion to produce what I call durable changes which almost certainly involve changes in neuroplasticity that is rewiring of brain circuits
And then finally is ketamine is very promising that we know from uh a lot of research and also my personal data that uh it is promising on uh the effects of PTSD of depression of opening therapeutic windows of uh change and also that it has the ability for the therapeutic window to be extended with um new research that was on animals not on humans.