David Sinclair· PhD
Elephants rarely get cancer, thanks to a gene that prompts apoptosis in response to DNA damage.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Elephants rarely get cancer, thanks to a gene that prompts apoptosis in response to DNA damage.
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Elephants have at least 40 copies of the tumor suppressor called “p53” per cell.
I don't think it is that they don't get cancer, I think what's amazing is that they're so big, right, and they have so many cells. And so you would think that there should be ways, there should be super ways they have of protecting against cancer because it's a hell of a lot of cell division to go from a single elephant egg and sperm, you know a zygote going to to an elephant which is so big. And there have been some studies on looking at for example, tumor suppressor mechanisms in some of these animals. P53 right, they have extra copies of p53.