Repeated daily use of stimulant medication in individuals with ADHD leads to progressively smaller peaks in dopamine response.

“equally important is the fact that it is the repeated taking of that drug by the child with ADHD or by the adult with ADHD that actually leads to lesser and lesser peaks in dopamine each time which is not to say that the person becomes entirely desensitized to the effects of the drug but rather that the system equilibrates through what's called homeostatic plasticity sometimes referred to broadly as habituation to a drug”