David Sinclair· PhD
Reminds me of a drawing in 1996, where DNA repair and gene expresion/silencing changes in the nucleus (and nucleolus!) of yeast are a primary cause of aging https://t.co/DXD4k4bC6c
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Reminds me of a drawing in 1996, where DNA repair and gene expresion/silencing changes in the nucleus (and nucleolus!) of yeast are a primary cause of aging https://t.co/DXD4k4bC6c
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this was years before Lenny Guarente and the team in 1997 saw rDNA instability cause yeast cells to age.
Next we showed SIR2/3/4 went to DNA breaks to suppress genomic instability, leading to sterility and premature aging (Cell, 1999)
From 1995-7, we worked together to show SIR4-42 relocalizes to the nucleolus constitutively, causing sterility, mimicking what happens during aging (Cell, 1997)
Next, Kevin, Lenny and I reported that prematurely aged yeast cells also showed accelerated movement of SIR2/3/4 to the nucleolus, where the genome was hyper unstable, and this gave rise to premature sterility, a hallmark of yeast aging (Science, 1997)
it's the actual the the movement of surtout protein away from those genes that it should be at to go deal with other problems in the cell
well in yeast it lead to accelerated aging through the process I was telling you about genomic instability DNA repair went went down