The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So, you know, getting your whole genome sequenced in the early 90s was when Venter and those guys first first nailed that ability. Something like that. I'm thinking 90s sometimes. Okay, maybe I'm a little early. Um, we're a little late on that one, but was extremely expensive, but now it's like what, a hundred bucks or or even free depending on the coverage. Yeah, you can sequence a genome for pretty cheap these days.
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Witness the future: the $100 genome is here. 20 years ago it cost a billion $.
A San Diego startup just made whole genome sequencing cost $100. It used to cost $1 billion + The Human Genome Project took 13 years (1990-2003), billions of dollars, and an international consortium of 20+ institutions to sequence one genome.
in the year 2000 it cost $1 billion to sequence a human genome today it costs $1,000 so that's a six log reduction in cost
yeah yeah so it was a series of inventions that allow the sequencing reactions to be miniaturized um and then you could do you know orders of magnitude more sequencing uh of of DNA by miniaturizing it um and so um you know the older sequencers they had a small glass tube and as the DNA went through you sequenced it um it got converted into a 2d format kind of like a glass slide where you had tiny um fragments of DNA stuck to it you know um hundreds of millions then ultimately billions and then you sequenced all of them simultaneously so there was a huge miniaturization of um each individual sequencing reaction which allowed you to just you know in one system generate many many more um DNA sequences at the same time
and I I feel like I looked at this on a graph a while ago and it was one of the few things I noticed that was improving faster than Moore's Law
so what was the state-of-the-art in transitioning that from where it was let's just say order of magnitude $10 to the9 per sequence to where it was 10 years later approximately what was what was the technology introduction or plural version of that question that led to a reduction and um how many logs did it improve by yes so the the number that and we went back and did this analysis so if you literally at the end of the original Human Genome said hey I want to do one more and you have the benefit of all the learnings right from from the previous one uh a few hundred million dollar um would have been incremental genome got it by um 201 12 it was you know on the order of low tens of thousands of dollars right so um uh you know let's call that you know four you know four or five logs of improvement
by 201 12 it was you know in the order of low tens of thousands of dollars right so um uh you know let's call that you know four you know four or five logs of improvement
Sequencing is now over 10 million fold cheaper, and most people can get their genome sequence inexpensively if they so desire.