David Sinclair· PhD
Loss of gene control leading to cell senescence may cause aging, driven by gene regulators like the NAD-dependent Sirtuins having to go repair broken DNA.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Loss of gene control leading to cell senescence may cause aging, driven by gene regulators like the NAD-dependent Sirtuins having to go repair broken DNA.
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it works in concert with the sirtuin end right and they all need nad
it's activity goes down with age coincident and probably caused by lower levels of nad as as the animals got older
they're probably just as important for this story
one of the foundational central pieces of aging appears to be dna damage this has been talked about so long this is where the sirtuins come in and nad and when nad runs out the so two ends can't do their job well the certains are involved in this dna repair and as are the parps
the sirtuins are involved in this dna repair and as are the parps you know the p parp uh enzymes
this is where the cerin come in and NAD and when NAD runs out the cin can't do their job well the cins are involved in this DNA repair
increased DNA damage and inflammation as seen in aging may decrease nad and potentiate aging
so not too much of a surprise but genomic stability which relies on nad in general and PARP one specifically may be very important for longevity
what drives aging, not totally, but to a large degree, is this competition between the sirtuins repairing DNA, as we get more and more damage over the years, and controlling your epigenome.