Andrew Huberman· PhD
So, a very influential hypothesis, which has guided my thinking. And again, the trick, you have done a wonderful job of communicating complex scientific topics to your podcast audience, and I congratulate you on that, and it's a really important role. But as you know, it's always more complicated than we want it to be as scientists, especially when you're dealing with brain activity issues and how the brain mediates all its amazing functions. So, historically, we have thought about the nucleus accumbens and other components of this ventral striatal brain area as primarily being composed of two different cell types, and as you pointed out, one being sort of an accelerator, something that promotes certain behaviors, and the other cell type somewhat being a break saying, don't do that behavior, don't perform that motor action. And it is true that there are these different cell types. It is true that they are modulated by these modulators like dopamine and serotonin in different ways. And that simplistic hypothesis, or heuristic we call it, has been very useful in making models about how the accumbens does all its wonderful things.