Overexpressing sirtuins in yeast leads to longer lifespan, a finding reproducible in many, but not all, strains.

“he overexpressed sir two um and lo and behold the yeast lived longer”

“where we'd found that up-regulating the sirtuin gene in yeast extends their lifespan.”

“that was really the first example of a conserved genetic modifier of lifespan across two widely evolutionarily divergent organisms”

“if you activated or over expressed a sir to and in this case it was sir to the founding member of the sirtuins in yeast that you could extend lifespan and slow aging”

“in fact most people ignore the other yeast sirtuins but they're just as interesting and what we found is they also can extend lifespan as well”

“the yeast sirtuin which is called sir two that's where sirtuin comes from so the yeast protein is called sir two if you over express sir two you increase lifespan and yeast”

“if you overexpress the yeast sirtuin which is called sir two that's where sirtuin comes from so the yeast protein is called cer2 if you overexpress sir two you increase lifespan in yeast”