David Sinclair· PhD
In this paper, we hypothesize that epigenetic changes are a cause of mammalian aging and show DNA damage is a trigger...
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
In this paper, we hypothesize that epigenetic changes are a cause of mammalian aging and show DNA damage is a trigger...
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dna damage is is part of it — when we go out in the sun we get dna damage if we have chemotherapy or yeah and radiotherapy we damage dna and we see that that accelerates this loss of epigenetic information
when we go out in the sun we get dna damage if we have chemotherapy or yeah and radiotherapy we damage dna and we see that that accelerates this loss of epigenetic information so in some ways they're connected so there was this dna theory of aging right that dna damage was creating aging and this kind of this wraps it back into it saying that if you're getting more dna breaks whether they're single standard or double stranded what you might actually be having is loss of epigenetic coding lots of epigenetic information that is methylation on histones and a variety of other proteins around which dna is wrapped and that that might be sort of the arbiter of aging