Bryan Johnson· Author
This epigenetic pattern constitutes a unique “longevity signature” that allows men to reach older age by suppressing the risk of multiple risk factors including age related diseases.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
This epigenetic pattern constitutes a unique “longevity signature” that allows men to reach older age by suppressing the risk of multiple risk factors including age related diseases.
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Compared with all other segments, older men had 3035 unique differentially methylated genomic units DMUs, possibly contributing the the percentage of DNA-methylation in longer-lived men.
Long-lived men have a unique epigenetic longevity signature protective from age related disease and other mortality risk-factors.
Both long-lived men and women had less DNA methylation than their younger midaged counterparts, however long-lived men demonstrated significantly increased DNA-methylation compared to long-lived women.
A study published this week identified specific DNA-methylation patterns exclusive to long lived men and found that these methylation spots (called DMUs) hit genes associated with age related diseases and other mortality risk factors more prevalent to men.