The ventromedial hypothalamus contains distinct neuronal populations that can either promote or inhibit feeding, leading to paradoxical effects on hunger and satiety.

“what they found was that sometimes lesioning or disrupting the neurons in the ventromedial hypothalamus would make animals or people hyperphagic they would want to eat like crazy and other lesions in other individuals or animals would make them anorexic it would make them not want to eat at all it would make food aversive so that means that the ventromedial hypothalamus is definitely an interesting control station for hunger and feeding and satiety but it doesn't really tell you what's going on at a deeper level in fact it's a little bit confusing or paradoxical turns out that there are multiple population of neurons in there some are promoting feeding and some are promoting not feeding or not eating”