David Sinclair· PhD
That gives real hope that aging is biologically malleable & perhaps, one day, medically treatable 🙏
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
That gives real hope that aging is biologically malleable & perhaps, one day, medically treatable 🙏
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
For decades, aging was studied mainly through metabolism, damage accumulation, or genetics. Increasingly, the field is exploring whether loss of epigenetic information may be a major driver of aging across tissues
And if that information remains stored within cells, as a growing body of evidence suggests, it may be possible to restore it.
Aging isn’t the buildup of damage, it’s the loss of information.
loss of primarily epigenetic information--including DNA methylation, the basis of clocks--is a cause of aging, one that is reversible using reprogramming methods...
and the epigenome being a recognized driver of aging
we know that epigenetic changes are part of biological aging this again is a different question but if we look at the Hallmarks of Aging epigenetic disregulation is one of the 12