Physiology follows hormetic curves, meaning there is an optimal dose for benefit, with too little or too much causing detriment.

“Physiology has hormetic curves. Right, now typically we think about this in terms of toxicology. So what this means is at some point giving you a dose of something, testosterone's a very easy example. If you're clinically deficient or low in testosterone, and I give you a little bit, and it brings you back into a normal range, you generally see an improvement in health and functionality. Taking you though from normal to super high, doesn't always necessarily provide additional benefit. In fact, if you continue to go, it's going to provide detriment, right? So everything has this curve.”