The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
methylglyoxol promotes oxidative stress and endothelial dysfunction that's not good The conclusion of this study which is done in rats is that the present study provides further evidence for methylglyoxal as one of the causative factors in the pathogenesis of atherosclerosis and the development of macrovascular diabetic complication
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it's a highly reactive dicarbonyl metabolite formed during glucose protein and fatty acid metabolism especially during fatty acid metabolism as we know during ketosis levels are 2.12 Times Higher on an Atkins Diet with ketosis than they are doing glucose metabolism
in excess of methylglyoxal formation can increase reactive oxygen production and cause oxidative stress
is methylglyoxal the hidden enemy it's a highly reactive dicarbonyl metabolite formed during glucose protein and fatty acid metabolism especially during fatty acid metabolism as we know during ketosis levels are 2.12 Times Higher on an Atkins Diet with ketosis than they are doing glucose metabolism they're elevated in hyperglycemia and other conditions in excess of methylglyoxal formation can increase reactive oxygen production and cause oxidative stress methylglyoxal reacts with proteins DNA and other biomolecules and is a major precursor of advanced glycation end products