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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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There are NO hidden dangers in fruit and honey — Whalespan

Content›Video›There are NO hidden dangers …

There are NO hidden dangers in fruit and honey

Paul Saladino14m · 2022-12-12

Claims Made

23

Claims Supported

17

Support Rate

74%

Support rate

17 of 23 claims supported

17 supported6 partial / not

Claims from this content

20

✓Well SupportedConsuming red orange juice for seven days ameliorates endothelial function and reduces inflammation in non-diabetic subjects with increased cardiovascular risk.✓Well SupportedCarbohydrates can lead to lower levels of advanced glycation end products like methylglyoxal, which are increased in individuals on ketogenic diets.✓Well SupportedMethylglyoxal, a harmful advanced glycation end product, is significantly raised in individuals following both low-carb and ketogenic versions of the Atkins diet.✕Not SupportedKetogenic diets increase advanced glycation end products, specifically methylglyoxal, which is detrimental to aging and oxidative stress.Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Fructoseamine measures average blood glucose over 2-3 weeks and can correlate with Hemoglobin A1C.

✓Well SupportedFructose in whole food forms like fruit and honey is not harmful for humans, unlike pure fructose or high-fructose corn syrup.

✓Well SupportedExcess fructose consumption in mammals leads to a rise in hemoglobin A1c and fructosamine, indicating glycation.

✓Well SupportedMethylglyoxal promotes oxidative stress and endothelial dysfunction, contributing to atherosclerosis and macrovascular diabetic complications.

◐Partially SupportedWhole food fructose from fruit and honey does not cause pathological levels of hemoglobin A1c.

◐Partially SupportedFruit is healthy and does not cause problems like fatty liver or diabetes.

◐Partially SupportedPure fructose-fed rats showed a significant increase in fructosamine and hemoglobin A1c compared to water-fed rats.

◐Partially SupportedReplacing other foods with fructose can lead to a decrease in hemoglobin A1c.

◐Partially SupportedIn rats fed fructose, sucrose, or glucose for one year, blood glucose levels were similar, but blood fructose levels were highest in the pure fructose group.

◐Partially SupportedSubstituting fructose-containing foods often leads to a drop in hemoglobin A1c.

✕Not SupportedHigh-fructose corn syrup is harmful for humans, supported by human trials and rodent studies.

✕Not SupportedFructose consumption does not significantly increase fructosamine or hemoglobin A1c levels in mammals.

◐Partially SupportedRodent studies showing fructose is harmful should not be directly extrapolated to humans.

◐Partially SupportedBlood orange juice provides early protection of mononuclear blood cells from oxidative DNA damage.

◐Partially SupportedMethylglyoxal may contribute to aging through oxidative stress.

◐Partially SupportedFruit consumption protects against oxidative stress and improves endothelial function, improving cardiovascular health.