Children born without the sodium channel 1.7 experience no pain, leading to dangerous injuries.

“For instance, I will tell you just now that there is a mutation, a genetic mutation in a particular sodium channel. A sodium channel is one of these little holes in neurons that allows them to fire action potentials. It's important to the function of the neuron. It's also important for the development of certain neurons, and there's a particular mutation, there are kids that are born without this sodium channel 1.7, if you want to look it up. Those kids experience no pain, no pain whatsoever, and it is a terrible situation.”

“Those kids experience no pain, no pain whatsoever, and it is a terrible situation. They burn themselves. They tend to rest on their limbs too long. They don't make the microadjustments. You might see me swiveling around in my chair, moving around a lot. Those microadjustments are actually normal, healthy microadjustments that prevent us from going into pain. They don't make those adjustments. They don't get the feedback that they're in a particular position and so they never make those adjustments and their joints get destroyed, essentially. They don't tend to live very long due to accidents. It's a really terrible and unfortunate circumstance.”

“there is a mutation a genetic mutation in a particular sodium Channel a sodium channel is uh one of these little holes in neurons that allows them to fire Action potentials it's important to the function of the neuron it's also important for the development of certain neurons and there's a particular mutation there are kids that are born without this sodium Channel 1.7 if you want to look it up those kids experience no pain no pain whatsoever and it is a terrible situation um they don't tend to live very long due to accidents it's a really terrible and unfortunate circumstance”