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Weekly · Sunday Morning

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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Control Pain & Heal Faster With Your Brain | Huberman Lab Essentials — Whalespan

Content›Video›Control Pain & Heal Faster W…

Control Pain & Heal Faster With Your Brain | Huberman Lab Essentials

Andrew Huberman37m · 2025-01-09

Claims Made

61

Claims Supported

47

Support Rate

77%

Support rate

47 of 61 claims supported

47 supported14 partial / not

Claims from this content

55

✓Well SupportedAging can be a nonlinear process with significant jumps in aging markers.✓Well SupportedSleeping with the head turned to the side may enhance the brain's cleansing capacity.✓Well SupportedRest and sleep are essential for TBI recovery, allowing the glymphatic system to clear debris and repair neurons.✓Well SupportedIncluding Zone 2 cardio weekly helps engage all eight mechanisms of exercise-induced brain improvement.✓Well Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Children born without the sodium channel 1.7 experience no pain, leading to dangerous injuries.

✓Well SupportedZone 2 cardio, low-level walking, and slow-wave sleep are recommended for brain longevity by keeping the glymphatic system chronically active.

✓Well SupportedViewing a picture of a romantic partner reduces pain by activating an oxytocin-linked mechanism.

◐Partially SupportedInflammation is a beneficial process for healing injuries, whereas chronic inflammation is detrimental.

◐Partially SupportedPhantom limb pain occurs when the brain's representation of an amputated limb remains intact and its activity levels ramp up due to lack of proprioceptive feedback.

◐Partially SupportedPlacebo effects and belief effects profoundly impact the experience of noxious stimuli like pain, as well as positive stimuli.

✕Not SupportedClaims that platelet-rich plasma (PRP) contains significant numbers of stem cells are unsubstantiated and it is illegal to advertise PRP using the term 'stem cells'.

◐Partially SupportedPain is a perceptual experience influenced by beliefs about bodily sensations, with implications for healing.

◐Partially SupportedAdrenaline release from practices like Wim Hof breathing and ice baths can counter infection, but the duration of the adrenaline response needs regulation.

◐Partially SupportedThe recency of a relationship directly correlates with an individual's ability to use internal representations of love to blunt pain responses.

◐Partially SupportedWim Hof breathing involves hyperventilation, exhalation, and breath holds, and liberates adrenaline to counter infection and stress.

◐Partially SupportedThe pain system can be leveraged to understand the difference between injury and pain and to interpret pain signals.

◐Partially SupportedTwo-point discrimination can determine the sensitivity of a body part and its corresponding brain area based on receptor density.

✕Not SupportedApplying ice to an injury primarily acts as a placebo and can negatively affect healing by causing clotting.

◐Partially SupportedIndividuals with mutations in pain-sensing receptors lack inflammation and experience joint disintegration.

✓Well SupportedInflammation can be a beneficial physiological response and a signal that something needs correction.

◐Partially SupportedDopamine and norepinephrine can activate the vagus nerve peripherally, which reduces inflammation.

◐Partially SupportedIntense stimulation of the abdomen and other areas can be pro-inflammatory by triggering loops that activate anxiety pathways.

◐Partially SupportedNociceptors are sensors that detect harmful stimuli, and 'nociception' is preferred over 'pain' by neuroscientists.

◐Partially SupportedNeural plasticity can be rapid and is driven by experience, such as visual input.

◐Partially SupportedThe subjective interpretation of a sensory event dictates the experience of that event.

◐Partially SupportedPeer-reviewed studies support the use of acupuncture for gastrointestinal tract issues.

◐Partially SupportedNon-steroidal anti-inflammatory drugs block prostaglandin pathways like COX enzymes.

◐Partially SupportedStem cells have the potential to differentiate into unintended cell types, including tumor cells.

◐Partially SupportedAnticipating pain relief can immediately reduce the perceived pain.

◐Partially SupportedIntense stimulation of the abdomen via electroacupuncture can increase inflammation through the splenic-spinal sympathetic axis, which can be beneficial against bacterial infections.

◐Partially SupportedLarge areas of the body with low sensitivity that experience injury are likely to experience less pain and heal more slowly due to fewer surrounding cells available for inflammation.

◐Partially SupportedIndividuals who produce excessive amounts of certain pain receptors experience extreme pain from even subtle stimuli.

◐Partially SupportedStimulating specific maps on the body surface communicates with the autonomic nervous system, releasing neurotransmitters that control alertness or calmness.

◐Partially SupportedImproving fluid perfusion through mechanisms like deep sleep, elevated feet, side sleeping, and Zone 2 cardio can aid recovery.

◐Partially SupportedFor managing injury and promoting fast healing, essential steps include ensuring at least 8 hours of sleep and a 10-minute daily walk, unless pain is excruciating.

◐Partially SupportedThe somatosensory system uses specialized neurons to detect mechanical touch, temperature, and vibration.

◐Partially SupportedStem cell use for localized injuries requires molecular restrictions to prevent tumor formation.

◐Partially SupportedAcupuncture and electroacupuncture work through discrete neural pathways linked to dopamine and specific organs.

◐Partially SupportedThe pain system is highly susceptible to perceptual influences, as shown by phantom limb pain relief with mirrorbox therapy.

◐Partially SupportedHeat therapy is beneficial for injury recovery by improving tissue viscosity and enhancing fluid clearance and profusion from the injury area.

◐Partially SupportedTop-down modulation of pain using cognition and senses is a skill that can benefit everyone.

◐Partially SupportedThe somatosensory system is influenced by cognitive components, peripheral input, and its integration with the autonomic nervous system.

◐Partially SupportedAdrenaline release can significantly blunt the experience of pain by binding to specific receptors and shutting down pain pathways.

◐Partially SupportedAcupuncture influences alertness and calmness by communicating between the somatosensory system and the autonomic nervous system.

◐Partially SupportedExtreme caution should be exercised with any stem cell therapy.

◐Partially SupportedNeuroplasticity of perception directly impacts emotional pain and trauma.

◐Partially SupportedA mirror box can provide immediate relief from phantom limb pain by remapping the representation of the hand.

◐Partially SupportedThe brain's representation of the body surface integrates external sensory and internal visceral information to create a representation of self.

◐Partially SupportedA solution for phantom limb pain demonstrates the capacity for top-down modulation of perception.

◐Partially SupportedStimulating pathways that activate the adrenals leads to the release of norepinephrine and epinephrine, which bind to beta-noradrenergic receptors, activating the spleen to liberate cells that combat infection.

◐Partially SupportedLove can modulate the pain response through top-down mental mechanisms.

◐Partially SupportedAreas of the body with denser receptors are more sensitive to pain.

◐Partially SupportedGenetic variation in pain receptor expression affects individual pain sensitivity.

◐Partially SupportedTreatments that reduce inflammation may not be optimal at the initial stage of an injury when inflammation is beneficial for cleanup.

◐Partially SupportedAcute inflammation is essential for healing, while chronic inflammation is detrimental.