We know from this study entitled "Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans" showed really nicely, I think. That if people are injected with E. coli, a bacteria it's actually an end-- they did this through endotoxin injections. People got really sick. They'd get feel like they had the flu, they vomit, diarrhea, get a fever, et cetera. However if they did the sorts of breathing that I talked about just a moment ago, prior to that, they were able to ward off a lot of the symptoms associated with the endotoxin infection.