David Sinclair· PhD
Epigenetic changes are likely one cause of aging but whether they are a primary cause or just one of 12+ equally important Hallmarks of Aging is still debated
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Direct evidence is thin. The claim is plausible and aligns with adjacent findings, but there isn't yet a body of high-quality work that would let us call it well-supported on its own terms.
Epigenetic changes are likely one cause of aging but whether they are a primary cause or just one of 12+ equally important Hallmarks of Aging is still debated
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
I think the question of the primacy of the epigenome is an open question. Nobody knows the answer to this. How testable is the hypothesis? How would you design the experiment to test that?
I suspect you would have a significant impact on those things but not fully restore them.