David Sinclair· PhD
If something doesn’t make a mouse live longer it won’t in humans
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
If something doesn’t make a mouse live longer it won’t in humans
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
testing a drug in humans with lifespan as an endpoint is almost hopelessly slow and almost hopelessly expensive the ideal animal for making a test of that is the mouse
if you have a drug that extends Mouse lifespan I think that's a critically important step towards making a case that it's slowing aging but it's not the last step