Andrew Huberman· PhD
Now, the problem is, it does make it into systemic circulation. The issue is also, that topical application of finasteride is harder to dose than oral finasteride.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Now, the problem is, it does make it into systemic circulation. The issue is also, that topical application of finasteride is harder to dose than oral finasteride.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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the topical finasterides are actually creating lower overall systemic concentrations of finasteride, that is not necessarily the case.
The topical finasteride were designed with the hope that the finasteride would make it into the hair follicle, and would inhibit DHT there and allow for more growth of the hair, which apparently it does, but not make it into the systemic circulation, or at least not at concentrations sufficient enough to cause as many side effects as with the oral dosing.