David Sinclair· PhD
how the Information Theory of Aging emerged
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
how the Information Theory of Aging emerged
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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The Information Theory of Aging (ITOA) posits that epigenetic noise expressed as Shannon’s entropy is a cause of aging.
It also posits something that was considered crazy a few years ago - that there is a "back-up copy" of the software in every cell that can be used to rejuvenate organs
ITOA posits that a loss of epigenetic information is the cell's long-term Achilles' heel.
What if aging is a symptom of cells losing the ability to read their genome - and there’s a reset switch? That’s the idea behind the Information Theory of Aging (ITOA) A new paper @NatureComms by Cohen et al provides strong support for the model & its reversibility 🧵👇 https://t.co/V67LxFTRY9
If so, aging isn't an extension of embryonic development, it is the software getting corrupted over time. Fortunately, we can reboot
The formal version of the Information Theory of Aging was first formulated in 2014 while I was in Fiji and was later described in my book Lifespan: Why We Age—and Why We Don’t Have To Die.
This is what the Information Theory of Aging predicts and, if correct, means aging is reversible.
Cells can be reset to regain identity
supporting the Information Theory of Aging, the concept that our bodies are biological computers running on software that becomes corrupted over time but can be reinstalled...
In our lab, this is exciting because we are working on the Information Theory of Aging (ITOA), which states that the loss of epigenetic information is a main cause of aging, and one that’s reversible, thanks to a back up copy of youthful information in every cell
If the ITOA holds, then it may be possible to rejuvenate our organs by resetting the epigenome. This may prevent or cure a variety of diseases, thereby extending healthy lifespan.
These changes are reversible via mechanisms currently unknown