David Sinclair· PhD
the process of "ex-differentiation" in which cells begin to lose their identity
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the process of "ex-differentiation" in which cells begin to lose their identity
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there's an analogy which is called Warrington's landscape where in the 1950s Waddington grew a picture it's a beautiful picture of some hills it's a mountain scape and cells actually roll down the mountain scape and land in different valleys down below and that's - before we had he had access to the genome that was his way of saying this is how cells know what they are they land in these valleys and they stay there but what I think is happening during aging is due to the vibration of noise over time we lose that pattern of gene expression we lose that information of genetic information and those cells or those marbles in Warrington's landscape they jump over into different valleys and lose their identity