Andrew Huberman· PhD
And the upper part of the pear has fear neurons.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And the upper part of the pear has fear neurons.
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That they all seem to be closely intermingled with each other, maybe because crosstalk between them is very important to help the animal's brain decide what behavior to prioritize and what behavior to shut down at any given moment.
if you activate those neurons and the mouse has a chance to be in one of two compartments in a box, they will gravitate towards the compartment where those neurons are activated, it has a positive valance.
And there's some evidence that those female-selective neurons in VMH are part of the mating behavior. If you shut 'em down, the animals don't mate as effectively as they otherwise would.
there's just recently a paper showing there are thermoregulatory neurons in VMH as well.
And it's not just fight and flight. There are also metabolic neurons that are mixed together in VMH as well.
If you think of ventromedial hypothalamus like a pear sitting on the ground, the fat part of the pair near the ground is where the aggression neurons are, but the upper part of the pair has fear neurons.
And the female VMH, the mating cells are only found in females. they are female specific and not found in the male brain.