Stimulating fascia in a particular location can activate a pathway to the adrenal medulla, leading to the release of potent anti-inflammatory chemicals.

“And so what they discovered is there's a specific population of neurons. Those neurons have a name, as they often do in science. Name isn't important, but if you want to look it up, it's the PROKR2 neurons, P-R-O-K R2 neurons. And they send a connection deep into the limb fascial tissue, okay? And then they send another connection, the connections we're referring to are axons, neurons have axons. So a wire in one direction that goes into the deep fascial tissue of the lower limb, near the calf and thigh. And then they send another wire up into the spinal cord, into a region of the hind brain in the back of your brain kind of near your neck in the medulla oblongata, that neuron also has a name called the DMZ, doesn't matter. And that neuron connects to the adrenal gland to release our good old friends, the catacholamines, noradrenaline, adrenaline, and dopamine, or norepinephrine, epinephrin, and dopamine. And their release causes a reduction in inflammation, even in response to an injection of something called lipopolysaccharide, which can actually induce fever.”