The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
the other thing that worked is 17 beta sorry 17 Alpha estradiol and it only worked in male mice so again suggesting that um well we can come back to that it's more than we want to get into at the moment but Point here is there are very molecules that have withstood the scrutiny of the ITP
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in NIA NIH triple site gold standard mouse lifespan studies, it caused 16% median and 17% maximum lifespan gain in wild type *male* mice (not tested in females)
that was enough to get it through the steering committee and when we gave it to mice it indeed had a terrific effect on male life
the 17 alpha estradiol in cohort 5 extended median survival in males but not maximum and of course no it doesn't well that was used at a low dose at a low dose when we went back and we did it at a three times higher dose it extends our measure of maximum longevity as well as median longevity
when we gave it to mice it indeed had a terrific effect on male life span it had no effect whatever now in in three separate studies in female life span in fact the males given the drug live not only longer than regular old males they live longer than regular females
it's not merely moving the male curve to be coincident with the female curve it's moving way past where the normal females live
17 Alpha estradiol this continues to work in male mice and it produces comparable effects to rapamycin
if you give 17 alrol to male mice it pushes their lifespan Way Beyond females it's not merely mimicking the good stuff that estrogen 17 beta does in females if so it wouldn't go fur than seven females are and it goes well beyond significantly Beyond normal females or drug treated females because the drug doesn't affect female longevity at all
the hydroxy version of estriol is great for males it's actually at least as good as 17 alestra Dial we won't know till we have the last few deaths but it's terrific that was a good guess you don't need 17 Al estra diol because the estriol works terrific