Andrew Huberman· PhD
The germ cells are supposed to be the only cells that contribute to the next generation, out of which the next generation will be made. So each of us is made just from a combination of a sperm and an egg.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The germ cells are supposed to be the only cells that contribute to the next generation, out of which the next generation will be made. So each of us is made just from a combination of a sperm and an egg.
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Even if you somehow acquire the mutation or a change in your DNA in one particular brain cell, it wouldn't matter, because this mutation, there's no way to transfer it to the DNA of the germ cells that will contribute to the next generation.
Mutation has to occur in egg or sperm to be passed on.