Topical treatments are often ineffective for significant skin conditions like acne, with many patients requiring oral medications such as isotretinoin.

“topicals aren't great for like versing a lot of skin uh conditions even acne patients right they uh they struggle they try every topical in the market and the family doctor can't solve it and they see a DM and then they have to do some you know oral isotron or barutan I think is the name in um in USA”