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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Blueprint Livestream / Nov 17th 2023 — Whalespan

Content›Video›Blueprint Livestream / Nov 1…

Blueprint Livestream / Nov 17th 2023

Bryan Johnson1h 16m · 2023-11-17

Claims Made

130

Claims Supported

93

Support Rate

72%

Support rate

93 of 130 claims supported

93 supported37 partial / not

Claims from this content

93

✓Well SupportedBryan Johnson's daily macronutrient intake is 2250 calories, with 130 grams of protein (~25%), 206 grams of carbohydrates (~35%), and 101 grams of fat (~40%).✓Well SupportedBryan Johnson's physiological data represents a benchmark for human health optimization.✓Well SupportedPlasma exchange between Bryan Johnson, his son, and his father was an effective experience, particularly for his father.✓Well SupportedBryan Johnson follows a program called Blueprint, adhering to scientific evidence and data, eliminating personal choice regarding food intake.Well Supported

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Bryan Johnson's Blueprint Rapamycin Protocol

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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✓

A 2012 study showed that 300mg of ashwagandha twice daily led to significant reductions in perceived stress and serum cortisol levels by day 15, 30, and 45.

✓Well SupportedHuman growth hormone intervention has shown potential to reinduce thymogenesis and increase naive T-cells, even in older individuals or those with HIV.

✓Well SupportedTransplanting young plasma into older mice can rejuvenate the brain, while transplanting old plasma into younger mice can accelerate aging.

✓Well SupportedBryan Johnson has achieved a non-detectable level of high-sensitivity C-reactive protein, indicating no systemic inflammation.

◐Partially SupportedCold-water immersion may negatively impact muscle growth by blunting pro-inflammatory responses and restricting circulation.

✓Well SupportedThe thymus shrinks and is replaced by fat after age 50, impairing vaccine response.

✓Well SupportedAshwagandha may help stimulate the body to secrete more endogenous DHEA and testosterone.

◐Partially SupportedBryan Johnson underwent a procedure involving injections of 300 million stem cells into six joints.

◐Partially SupportedA minimum daily dose of 25 mL of EVOO may reproduce clinical trial effects.

◐Partially SupportedFocused shockwave therapy applied to various body parts including the penis, feet, ankles, ACL, knees, and shoulders has been helpful for rejuvenation.

✓Well SupportedGlycine supplementation is more interesting than collagen for its potential benefits on glycemic control and sleep.

◐Partially SupportedKate, aged 28, has been on the Blueprint protocol for nearly 100 days and experienced significant cell turnover.

◐Partially SupportedTopical therapies, pills, or injections that dissolve cataracts would avoid surgery and the use of artificial lenses.

◐Partially SupportedHyperbaric oxygen therapy typically involves five 60-minute sessions per week at two atmospheres.

◐Partially SupportedSome laser hair therapy devices require 20 minutes every other day, while others, like laser caps, can be used for six minutes daily.

◐Partially SupportedThe 'super veggie' product is equivalent to 3.4 cups of fresh vegetables per serving and does not taste like vegetables.

✓Well SupportedMinimizing muscle loss during weight loss is achieved through adequate protein intake and strength training.

◐Partially SupportedBryan Johnson's father experienced meaningful cognitive decline before undergoing plasma exchange therapy.

◐Partially SupportedExtra virgin olive oil constitutes 15% of the Blueprint diet's caloric value, with a recommended intake of three tablespoons (45ml) per day.

◐Partially SupportedThe KSM-66 subtype of ashwagandha extracted using a milk or lipid-based solvent is recommended.

◐Partially SupportedBryan Johnson switched from PRP injections to exosomes for hair treatments due to the pain and swelling associated with PRP.

◐Partially SupportedThe chemical structure of extra virgin olive oil is healthier than non-extra virgin olive oil.

◐Partially SupportedAvoiding smoking cigarettes and secondhand smoke reduces 'bad' inflammation.

◐Partially SupportedBryan Johnson takes 3.6 grams of NAC daily.

◐Partially SupportedSunscreen is very important, especially in younger years, to prevent severe skin damage that manifests later in life.

◐Partially SupportedBlueprint Essentials contain 26 critical nutrients, and the overall Blueprint stack includes over 74 individual therapies at clinically relevant doses.

◐Partially SupportedA 10% caloric restriction yields the same health benefits as a previous intake of approximately 1950 calories, with the current intake increased to 2250 calories.

◐Partially SupportedOliver and Bryan Johnson drink mineralized water, tea, or electrolytes, but never plain water, due to insufficient electrolytes in plain water.

◐Partially SupportedDevices such as lasers, radiofrequency microneedling, HIFU, IPLs, and injections are more effective for significant skin treatment results than topicals.

◐Partially SupportedThe Audio Cardio app may help with tinnitus.

✕Not SupportedDry swallowing pills can lead to esophageal ulcers, fissures, or fistulas, and in severe cases, death.

✕Not SupportedCold exposure does not cure major diseases like Alzheimer's, cancer, or heart disease, nor does it reverse aging.

✕Not SupportedVerapamil is primarily for pre-diabetics or diabetics and other options are more evidence-based.

◐Partially SupportedOlive oil is included in the Blueprint protocol due to its association with the Mediterranean diet.

◐Partially SupportedWisdom tooth surgery, stress reduction, or reducing noise exposure can help resolve tinnitus.

◐Partially SupportedShockwave therapy is beneficial for the Achilles tendon, which ages faster than other tendons.

◐Partially SupportedThe cocoa powder used in the product has the highest polyphenol density among tested chocolate producers.

◐Partially SupportedSexual health management includes testing and behavioral strategies to reduce risk.

◐Partially SupportedStrength training for 30 minutes five times a week burns fat and preserves muscle.

◐Partially SupportedAdequate protein intake, around 1.6g per kilogram of body weight per day, ideally split into at least two sessions, can help minimize muscle loss during weight loss.

✕Not SupportedUsing HGH (Norditropin, 6 units 5 days/week) increased aging biomarkers by 0.8 to 0.9.

◐Partially SupportedThe Blueprint protocol includes a 'longevity mix' designed to replace most daily pills.

◐Partially SupportedTo measure inflammation, monitor CRP (aiming for under 1 mg/L) and white blood cell count (aiming for under 7).

◐Partially SupportedMinoxidil topical, finasteride topical, and tretinoin may be effective for hair loss, but genetic response varies.

◐Partially SupportedFocused shockwave therapy feels uncomfortable in tight or inflamed areas but is not painful.

◐Partially SupportedChlamydia tests may not be positive until two weeks after exposure.

◐Partially SupportedAttempting to solve aging in every organ simultaneously can lead to negative outcomes in other areas.

◐Partially SupportedSome cases of gonorrhea have shown resistance to first and second-line antibiotics, but it remains uncommon and generally has good cure rates.

◐Partially SupportedThe Linire device uses bimodal neural stimulation to signal the cochlea to turn off the tinnitus signal.

◐Partially SupportedWearing correct shoes and avoiding slippery surfaces can prevent ligament injuries from falls.

◐Partially SupportedExtra virgin olive oil meets criteria including being from the earliest harvest, pressed mechanically without solvents, not rancid, and having no taste or smell defects.

✕Not SupportedConsuming large daily quantities of red meat can be dangerous and lead to serious conditions like bowel cancer or heart disease.

◐Partially SupportedOlive oil is a great staple for everyone's diet.

◐Partially SupportedAshwagandha affects DHEA, testosterone, and other markers.

◐Partially SupportedProtandim, containing ashwagandha, increased mouse lifespan by 5-15% in an NIH study.

◐Partially SupportedCustom-fitted earplugs from Micro Sonic, costing $200-$300, can be used for hearing protection at loud events.

◐Partially SupportedWear custom orthotics if you overpronate or roll your feet inward while walking.

◐Partially SupportedThe Blueprint nutrition program is launching in January.

✕Not SupportedTopical treatments are often ineffective for significant skin conditions like acne, with many patients requiring oral medications such as isotretinoin.

✕Not SupportedTopical skincare treatments are often not effective for reversing significant skin conditions.

◐Partially SupportedMuscle loss can be minimized during weight loss, especially when going from a BMI above 25 to a healthier range.

◐Partially SupportedUrine testing is used for chlamydia and gonorrhea and is often free on insurance for certain demographics.

◐Partially SupportedThe foot is an organ system, similar to hands and other joints.

◐Partially SupportedCombination therapies, expert consultation, and hair transplants are recommended for hair loss in men.

◐Partially SupportedRejuvenating joints is complex due to multiple tissue types requiring different therapies.

◐Partially SupportedAshwagandha is part of the core supplement stack.

◐Partially SupportedSome individuals with autoimmune conditions or anemia may benefit from red meat consumption when heme iron supplements are ineffective.

◐Partially SupportedResponding with 'yes and' rather than defending oneself is better when criticized, as defense can worsen the situation.

◐Partially SupportedTaking approximately 100 supplements per day is an attempt to cover all possible bases rather than indicating a dietary insufficiency.

◐Partially SupportedBoth nmn and nr supplementation were effective in raising intracellular nad+ levels to an 18-year-old equivalent in bryan johnson.

◐Partially SupportedThe lens of the eye starts stiffening from age 10 onwards, leading to visible cataracts by age 40-50 on average.

◐Partially SupportedA 312-diode laser cap worn for six minutes daily can work for hair regrowth, but it is a slow process compared to topical treatments or PRP.

✕Not SupportedHighly processed red meat is a known carcinogen and can cause cancer and heart disease.

◐Partially SupportedDiet, exercise, and supplements like ginger, glucosamine, cumin, and cinnamon can help lower inflammation.

◐Partially SupportedIndividuals who are highly sexually active with different partners, intravenous drug users, hard drug users, immunocompromised individuals, or those with a history of previous STDs are at higher risk of contracting STDs.

◐Partially SupportedCardiologists do not prescribe cold plunges or saunas as treatments for cardiovascular health.

◐Partially SupportedProsthetic lenses in cataract surgery may offer enhanced focus and zoom functions within five to ten years.

◐Partially SupportedSimultaneously increasing multiple mouse lifespan study interventions is being tested for safety and organ benefits.

◐Partially SupportedChronic tinnitus can be caused by noise exposure or damage to the auditory system from drugs, including some antibiotics.

◐Partially SupportedPulsatile tinnitus is often more serious than high-pitched ringing tinnitus.

◐Partially SupportedTemporary ringing in the ears lasting 5-10 seconds is a natural reflex and not chronic tinnitus.

◐Partially SupportedCommon tinnitus can be caused by wisdom teeth issues, tooth infections, or stress.

◐Partially SupportedVaccines for Hepatitis A and B are recommended, especially for healthcare workers.

◐Partially SupportedThe feeling of hopelessness associated with depression is not an accurate reflection of reality and can be overcome.

◐Partially SupportedThe goal of musculoskeletal rejuvenation is to restore joints to an 18-year-old status.

✕Not SupportedSmoking one cigarette per week can increase CRP and white blood cell counts.

◐Partially SupportedAshwagandha may help with fat burning and muscle preservation but can potentially exacerbate depression and anhedonia in some individuals.

◐Partially SupportedAshwagandha may help minimize muscle loss during weight loss.

✕Not SupportedNon-KSM-66 subtypes of ashwagandha can sometimes cause liver side effects.