The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
We have now tools where we can in mice again we can look at every cell in the body of a mouse and we can ask how does to the cells in an old mouse respond to young blood. And what you see is that almost every cell changes their behavior when we measure their transcript. So their gene expression in these cells but they respond in different ways and it's expected because they have different what we call receptors.
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And again we could find some of them that really were more powerful than others.
where they they they take a fraction of like young uh Young plasma like some pits of young plasma concentrated that down and then injected that into older mice and then made them 50% younger on their epigenetic age epigenetic biological aging scores
A Growth factor found in plasma during youth can reverse tissue aging & stem cells when injected into old mice.
And then, more recently, people said, "Okay, well, maybe you don't have to connect them, you can just do this whole plasma-exchange method where you can put young plasma into an old mouse," and it seems to, in some ways, again, rejuvenate them. Not to use that kind of snake-oily term but that's the best we have. And actually, we've been doing this with cells in a dish. So, we actually buy serum from older individuals versus younger individuals and we can grow our cells in these two different conditions. And we, again, can age even fetal cells using old serum, the young serum seems to be not as problematic.
if I recall correctly he's also been involved in research where he's transplanted um young plasma into into you know older mice and sort of rejuvenated in the brain and it's like well are there proteins I think the opposite was done as well whereas old plasma was transplanted into younger mice and is sort of accelerated