Human growth hormone intervention has shown potential to reinduce thymogenesis and increase naive T-cells, even in older individuals or those with HIV.

“HGH yeah we we did HGH for 100 days for thymus Rejuvenation so your thymus is this organ right behind your sternum which is responsible for your immune system it's really really important uh a worn down thymus is uh one of the reasons why people die in older age their immune system just is not robust enough so we did a protocol using HGH to generate and uh over I think three two or three MRIs yeah we we showed that we rejuvenated my thymus uh by seven years”

“And growth hormone can stimulate that, but it comes with side effects as we mentioned, not least of which is increase in insulin insensitivity or glucose intolerance.”

“HGH had been shown previously to reconstitute the thymus. This is a little organ gland that's here in your chest that is important for the immune system. This is where your T cells, your immune cells come from, and growth hormone can stimulate the regeneration of this as it degrades over time.”

“And human growth hormone as you know is one of the the the intervention that has been shown to actually reinduce thyogenesis.”

“they in the patients they indeed observed some increase in na in the fraction of naive tea cells which tells you and me that something worked the fraction of naive tea cells increased um with respect to the memory tea cells, the naive tea cells are the ones that are generated in the thymus.”

“because there was indeed in the experiment um they in the patients they indeed observed some increase in na in the fraction of naive tea cells which tells you and me that something worked the fraction of naive tea cells increased um with respect to the memory tea cells, the naive tea cells are the ones that are generated in the thymus.”

“So the whole idea of treating with human growth hormone was to induce thyogenesis and to restore the pool of these naive tea cells.”