Andrew Huberman· PhD
So the sirtuins will mainly respond to sugar and insulin. And then there's this other system called mTOR, which is sensing how much protein or amino acids are coming into your body.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So the sirtuins will mainly respond to sugar and insulin. And then there's this other system called mTOR, which is sensing how much protein or amino acids are coming into your body.
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the genes that control aging (mTOR, AMPK, Sirtuins)
So the regulators we've talked about. We've got mTOR, that responds to amino acids, AMPK, which is blood sugar and energy, and sirtuins, which respond to both of those things and more.
And so that the three main pathways that control this: we've talked about mTOR, which is sensing the levels of amino acids in the cell. Lower levels of certain amino acids, branch chain amino acids, are good for the cell because they downregulate mTOR activity. That's one way. The AMPK senses energy, glucose; and then the sirtuin sense NAD, which is a molecule that goes up with exercise and hunger.
they are one of three major types of longevity gene um but interestingly that uh we used to fight over whose longevity gene was more important
so to me those are all diseases of excessive growth and therefore you have to start looking at growth pathways which actually are the exact same as metabolic pathways which is insulin mTOR AMPK which is important of course for metformin and then all of a sudden you see hey all of these times that you can decrease nutrient sensors that is decrease mTOR decrease insulin increase AMD k you're getting good effects for longevity