David Sinclair· PhD
It’s worth pausing to consider how remarkable it is that we find essentially the same longevity genes in every organism on the planet: trees, yeast, worms, whales, and humans
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
It’s worth pausing to consider how remarkable it is that we find essentially the same longevity genes in every organism on the planet: trees, yeast, worms, whales, and humans
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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how conserved are these across let's you know use the big four models of eukaryotes from yeast worms flies you know larger mammals like mice and rodents is this relatively well conserved the way the Tor pathway is conserved or does it have more bends in the road well they're surprisingly conserved
that's actually one of the advantages we have aging is actually not that difficult to be able to control and that's because our models are very good if we can I really believe that if we can extend the lifespan of a yeast or worm in a mouse humans are so close right that if you can do it across a billion years you should be able to make that leap to a few other hundred million
I 100% agree to you that whatever is the fundamental issue that happens in cells that leads to aging is going to be conserved and therefore The Regulators of that process or the impactors of that process will be conserved
because we already know that the genetics of longevity are conserved not everything's going to be conserved but it has been statistically shown that there is a conservation of the biology of aging
It seems like the compounds that are working in multiple different species are probably, you know, the best candidates, in my opinion.