Andrew Huberman· PhD
So what we've now know is that these longevity pathways, we call them these longevity genes, talk to each other.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
So what we've now know is that these longevity pathways, we call them these longevity genes, talk to each other.
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So these genes are working in concert with one another? - That's a really important concept, because about a decade ago, scientists like me, we were fighting over whose longevity gene was more important. [Matthew laughing] It was pretty pathetic. - And very typical of scientists. - Right. Everyone wants to be the smartest person in the room. But what we finally realized, 10 years ago, is that these genes talk to each other and they're part of a network, which actually is a blessing and a curse, because you can tweak one and affect the others. But now we're faced with which one is best to tweak, and if you tweak two out of three, or three out of three, is that good or is it bad? And that we'll get to, also, in later episodes. - Well, okay, and then if you said three now, so I'm hearing some similar things, and I think this is really important, one of which is that these genes are activated by stress. mTOR is. AMPK is.
they are one of three major types of longevity gene but interestingly that we used to fight over whose longevity gene was more important because the stakes are so low but the the ultimate you know that the old guard is now leaving the field the vicious ones but we you know the next generation of us and particularly our trainees much better and we all now generally agree that these various genes are talking to each other
there's really no comparison between the effects you get from inhibiting mtor and the effects at least so far that people have reported from from activating circuits mtor is head and shoulders above sirtuins when it comes to magnitude of effect
there's really no comparison between the effects you get from inhibiting mtor and the effects at least so far that people have reported from from activating sirtuins mtor is head and shoulders above sirtuins when it comes to magnitude of effect
all the pathways are important. In fact, they're all talking to each other. We showed that sirtuins and TOR are talking to each other.